The flower is also used for inflammatory conditions associated with arthritis and gout. Numerous studies have shown extracts of red clover to be safe and effective for hot flashes in particular. Red clover contains a mild sedative property, which complements its antispasmodic effects for cough. The isoflavone Biochanin A inhibited activity and gene expression of aromatase, an enzyme that catalyzes the conversion of androgen to estrogen (2). Preclinical studies suggest red clover extract may act as an estrogen agonist and stimulate proliferation of ER-positive breast cancer cells (1). Here are a few of the most common uses. General information: If you have any questions about red clover leaf extract, please talk with your doctor, pharmacist, or other health care provider. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved t … Effects of red clover extracts on breast cancer cell migration and invasion Gynecol Endocrinol. Red clover leaf extract is to be used only by the patient for whom it is prescribed. Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. J Clin Endocrinol Metab. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Red clover contains isoflavone compounds similar to those found in soy. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. 2000;66:1281-91. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. Data from clinical trials suggest that supplementation with red clover isoflavones helps relieve menopausal symptoms. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Because red clover contains isoflavones that mimic the effects of the hormone estrogen once they enter the body, the safety of RC in patients with breast or endometrial cancer remains controversial. After postoperative re-hemorrhage, an intraoperative thromboelastogram confirmed that antiplatelet effects were more likely than coumarin toxicity. Clinical Consult: Assessing the Impact of Tailor X. In postmenopausal women, endometrial status was not adversely affected. Red clover has been used for hundreds of years as a natural herbal remedy to treat many different diseases, including joint problems, respiratory illnesses, muscular aches and pains (particularly mastitis), inflammation of the skin and other soft tissue, and many types of cancer. It’s used to make an herbal supplement that may have some immune-boosting and positive hormonal effects, especially for postmenopausal women. Dried red clover flowers have been used in traditional medicine to treat a wide spectrum of ailments, including jaundice, cancer, mastitis, joint disorders, and respiratory conditions (eg, whooping cough, bronchial asthma), and as a sedative. These include biochanin, daidzein, formononetin, and genistein. 2007;14:153-59. Until definitive data are available, patients should avoid use of red clover during radiotherapy for prostate cancer. Also, red clover may increase the effects of anticoagulants and antiplatelet drugs. There is no evidence that red clover can help treat cancer. Bleeding disorders: Red clover might increase the chance of bleeding. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. © 2020 MJH Life Sciences and Cancer Network. Coon JT, Pittler MH, Ernst E. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. Red clover is a wild plant belonging to the legume family. Atkinson C, Compston JE, Day NE, et al. Those with hormone-sensitive conditions, such as breast cancer, ovarian cancer, or endometriosis,... Drug interactions. Red clover has similar effects to estrogen and could complicate these conditions and interfere with treatment. Red clover is used to purify blood by enhancing urine, production of mucous, enhancing circulation and stimulating bile secretion. Her symptoms resolved after discontinuation of the supplement.. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. An isoflavone-enriched fraction showed neuroprotective activity in human cortical neurons as well, possibly due to antioxidant and estrogenic effects (4). In addition, here is an article from the Mayo Clinic mentioning how isoflavones in food such as soy are not sufficient to cause breast cancer, and in fact a lifelong diet including such foods actually reduces breast cancer: Read the article from the Mayo Clinic (Red clover is an herb, which is considered a food). Russian folk healers and traditional Chinese physicians have long used Red Clover for asthma, bronchitis and to clear the lungs. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. 2005;21:257-64. -Barrie Cassileth, PhD. 1999;84:895-98. Red Clover herb is a simple to find herb with many uses. Biochanin A (BCA) is a dietary isoflavone present in red clover. 1. Red clover is used in the treatment of skin complaints (especially eczema and psoriasis), cancers of the breast, ovaries and lymphatic system, chronic degenerative diseases, gout, whooping cough and dry coughs. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. 8. 2. In addition, it protected dopaminergic neurons against lipopolysaccharide-induced damage by inhibiting microglial activation and proinflammatory factors (3). Case reports Red clover is effectively treats menopausal symptoms and irregular menses. Neurocrit Care. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Gynecol Endocrinol. The herb has tumor-inhibiting properties and strengthens lymphatic functions (crucial in cleansing cell tissues). Red Clover for Bigger Breast – Side Effects. Br J Nutr. 2007;7:76-80. In one case, the issue resolved after supplement discontinuation. Not only does red clover and cancer treat cancer but also … Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Phytomedicine. Red clover contains substances called isoflavones. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. It is unclear whether red clover is safe for consumption by women with a history of estrogen-receptor (ER) positive cancer. But as you can see hormone support for her helps in treating cancer such as breast cancer if used before actually getting the cancer. 7. Please keep in mind that clinical studies have shown that some phytoestrogens have anti-cancer properties. Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. It has shown a definite limiting effect, however, in the development of benign prostate hyperplasia (BPH), which is a non-cancerous enlargement of the prostate gland. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Lukaczer D, Darland G, Tripp M, et al. Two: This is often used for children that have a persistent, bad cough. One study in menopausal women suggests that red clover extract can improve elasticity of major arteries. From radiation therapy to clinical trials to check-ins with your doctor, your care is made as convenient as possible. Red clover, although it does not cause cancer, is not to be played with! Two: This is often used for children that have a persistent, bad cough. Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells. Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. Otherwise there is no stand Red Clover Kills Prostate Cancer Cells By Michael A. Smith, MD More than 238,000 men will be diagnosed with prostate cancer in the United States, and nearly 30,000 will die from it. The plant was thought to purify the blood by promoting urine and mucus production, improving circulation, and stimulating secretion of bile. However, it is not known if red clover can protect against the development of heart disease, and this will also require more clinical trials. Red clover contains substances called isoflavones. However, its usage in many parts of the world as a traditional cancer remedy has prompted scientists to take a close look at the herb. Subarachnoid hemorrhage: In a 53-year-old woman following use of an herbal supplement containing red clover, dong quai, and Siberian ginseng for perimenopausal hot flashes. Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. 2007(4):CD001395. In a trial involving osteopenic postmenopausal women, a red clover extract rich in isoflavones, aglycones, and probiotics attenuated bone mineral density loss caused by estrogen deficiency and improved bone turnover (26). Downsides and side effects Side effects. More studies are needed. Red clover is one of the richest sources of isoflavones. Cattle and other animals graze on red clover. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Lethaby AE, Brown J, Marjoribanks J, et al. Here are a few of the most common uses. [1,2,3] However, conclusions from systematic reviews have been conflicting: one suggested marginal benefit, whereas another found no evidence of effectiveness. The controversy concerning the use of red clover for the treatment of cancer is twofold. Due to their partial selectivity of action on estrogen receptors (ERs) these compounds have been claimed to … Studies suggest it is not effective in treating hot flashes. Well, this can be dangerous, both for your breast and your liver! Avoid large amounts and use with caution. Like peas and beans, red clover belongs to the family of plants called legumes. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Potential interactions between alternative therapies and warfarin.  However, the red clover isoflavone biochanin A was shown to inhibit aromatase activity and expression, thereby conferring a protective effect. It’s possible that this herb may complicate these conditions and interfere with treatments, or even worse potentially raise the risk for them developing in the first place. Isoflavone-enriched extracts have shown neuroprotective effects in human cortical neurons (3) (4) and reduced skin aging in mice by increasing collagen (5). Dried red clover flowers have been used in traditional medicine to treat a wide variety of ailments, including jaundice, cancer, breast tissue infections, joint disorders, and respiratory conditions (e.g, whooping cough, bronchial asthma), and as a sedative. Nourishing food herbs like Red Clover have been used for thousands of years with no indication the plant contributed to estrogen dominant conditions or estrogen-sensitive cancers. Do not take red clover if on a blood thinner, or when using melilot an herb that enhances bleeding. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. Supplements containing red clover isoflavones do not adversely affect breast density, skeletal strength or cardiovascular status. Hidalgo LA, Chedraui PA, Morocho N, et al. However, compared to estrogen, which has relative high binding affinity for the ER-α and ER-β, isoflavones demonstrate up to ~1600 times lower affinity for ER-α meaning they should not increase the risk of cancer. Donate today. 2010;76:896-904. Red Clover roots have also been used to treat diphtheria. Red clover is a wild plant belonging to the legume family. There was no further bleeding after the patient was subsequently treated with tranexamic acid and platelet transfusions (6). Red Clover (Trifolium pratense) Red Clover (Trifolium pratense). Users of this Web site should not rely on information provided on this Web site for their own health problems. Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. Historically, red clover was used for asthma, whooping cough, cancer, and gout. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Was this article helpful? Red Clover tea, made from the red blossoms, was an old remedy for winter colds. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Anticoagulants / Antiplatelets: Preclinical studies suggest red clover may increase their effects (20). Red clover may also block enzymes thought to contribute to prostate cancer in men. Cochrane Database Syst Rev. 1 In fact, about one in six men will be diagnosed with this condition during their lifetime. Red clover is a favorite herb for women experiencing hot flashes and other hormonal changes throughout menopause, including vaginal dryness and osteoporosis. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. 2008;99:303-10. Isoflavones may also improve bone loss (11). Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer. A meta-analysis of a standardized extract suggests potential reductions in total cholesterol in peri- and postmenopausal women, but studies were heterogeneous (29). Isoflavones are effective in treating several conditions such as hot flashes, cardivascular health and osteporosis. The red clover plant actually belongs to the legume plant family (just like peanuts and beans), which is why animals often graze on it in the wild. Red clover contains substances called isoflavones. Keep red clover leaf extract out of the reach of children and away from pets. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns.
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