Why do you think you have mercury toxicity? … What side effects did you experience from Neurontin? Garlic prevented cadmium-induced kidney damage  and decreased the oxidative damage due to lead in rats . ALA isn't a drug that stays in your body binding to receptors or whatever until cleared out, it's a nutrient that gets absorbed, metabolized, utilized. Therefore, ALA supplements are preferably taken on an empty stomach to benefit of the acidic stomach pH. What is concerning to me, however, is that the Cutler Therapy purports a half-life of 3 hours where the literature shows a half-life of just over 30 minutes. https://www.amazon.com/R-Alpha-Lipoic-R-LIPOIC-count-STRENGTH/dp/B01M0QS5C7, There are many studies on its effectiveness available on the pubmed site. In this work, a comparative assessment of the effect of drugs (diazepam, phenibut and its isomers, hopantenic acid, pyritinol, piracetam and Phenotropil) on the indicators of stress-reaction of animals in three models of experimental stress, which received the … A more reasonable dosing regimen would be every 1.5 hours (and given my insomnia, I wake up at this rate anyway), which would result in fluctuations between around 125% and 25% dosing amounts. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Despite that fact, there has been a lot of recent interest in using ALA supplements. Much higher doses for way longer periods of time and saw no change. Tried on and off twice. (ii) Other natural polymers have also been gaining attention as potential adsorbents of heavy metals, such as algal polysaccharides alginate  and chlorella . A selenium yeast product increased mercury excretion and decreased oxidative stress-related biomarkers, particularly urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine . I have just began taking alpha-lipoic acid supplements, 300mg twice daily. Optim-ALA Optimized Alpha Lipoic Acid is a highly bioavailable alpha lipoic acid supplement from Natrium Health, the sister company of Nootropics Depot. It's not a "detox" reaction or from chelating heavy metals. Some folks say it helps as it acts as a glucose disposal agent, thus allowing slightly higher carb consumption without exiting ketosis. CDN$ 35.99 CDN$ 35. If you have confirmed that you have mercury toxicity, get a real chelating agent, preferably one actually backed by clinical evidence, and don't try an unproven treatment that doesn't sound likely to work and could be harmful. Frequent, low-dose Lipoic Acid in accordance with half-life, makes sense from a chelation perspective, especially so for lipoic acid given its relatively lower affinity for heavy metals compared to stronger chelators. Press J to jump to the feed. Yes. (iii) Given that toxic metals have a great affinity for sulfur-containing peptides, diets rich in sulfur-containing foods, such as alliums (e.g. Alpha-lipoic acid is most commonly taken by mouth for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. Lipoic acid is unique among other antioxidants because it is both water- and fat-soluble. Press question mark to learn the rest of the keyboard shortcuts, Lipoic Acid as a potential chelator for mercury, the literature shows a half-life of just over 30 minutes. Alpha Lipoic Acid: Half Life? Alpha-Lipoic acid is commonly referred to as ALA and Thiocitic acid. Chelation is central to the natural detoxification of heavy metals, via the formation of complexes, particularly with glutathione and other small molecules, and their excretion . A subreddit for those living with neuropathy. * R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. It aids the body in breaking down sugar and using it to fuel energy. Given the literature value, dosing according to Cutler Therapy would result in fluctuating between just over 100% and 1% blood levels, obviously suboptimal (and also below the clinical determination for elimination). Modified citrus pectin plus alginate products have been used successfully to reduce lead and mercury in case studies . Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. (iv) Glutathione is not recommended to be administered orally as it undergoes digestion; however novel modes of delivery, such as liposomal and prodrug preparations, are emerging . Alpha lipoic acid has helped me muscle twitches & neuropathy tremendously. (i) Dietary fibers from various food products, including bran from grains, as well as fruit, have been evaluated as an alternative or adjunct to chelation therapy, with the aim to interrupt enterohepatic recirculation [34, 35, 36], and to modulate intestinal flora , with findings of reduced levels of mercury in the brain and blood. The antioxidant alpha lipoic acid has been shown to increase insulin sensitivity and is used to treat people with diabetes. 5) Acetyl L-Carnitine and Alpha Lipoic Acid Price. garlic ) and brassicas (e.g., broccoli ) have been suggested for effects on glutathione, with hopes for symptomatic improvement and enhanced excretion. The formula cannot be purchased directly from the manufacturer’s website. Due to its potential antioxidant activity, … Alpha lipoic acid supplements are becoming increasingly popular with people who are looking to get more antioxidants, combat symptoms of diabetes and diabetic neuropathy, slow the damage done by liver disease or HIV, or to boost brain power. Yes, I've had that exact thing from a. lipoic acid too. Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC672318. They are rich in membranes, particularly of excitable tissues, and they decrease oxidative stress markers resulting from heavy metal exposure. 99. I've been doing some reading on ALA supplementation (Alpha Lipoic Acid, not to be confused with Alpha Lineolic Acid for Omega-3 supplementation). I'm intrigued by Lipoic Acid as a potential chelator for mercury , as I suffer from chronic mercury toxicity. (v) Selenium is an important essential element, that is present at a broad range of levels across populations. This is a unique & common antioxidant available in … Alpha-Lipoic Acid. Practitioners also report using taurine for 6 weeks or so prior to hair analyses, to boost levels and improve detection. After some research, I suggested she try taking the maximum recommended dose of alpha lipoic acid, which is an antioxidant that affects the brain. Lipoic acid, also known as Alpha-Lipoic acid, (ALA, Thioctic acid) is similar in structure and function to a vitamin. Without Alpha-lipoic acid, free radicals will form a chemical reaction that can lead to the emergence of diseases, such as stroke. It serves vital functions at the cellular level, such as energy production. Not only animals, but also plants produce chelating compounds , and the metallothionein content of foods may affect bioavailability, as well as metabolism of toxic metals . Optim-ALA Optimized Alpha Lipoic Acid utilizes two of the best, most bioavailable forms of R-ALA paired with sesame extract. Clinical experience is that it must be used carefully as it poses particular risks of redistribution of metals.
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